Over-the-counter pain relievers These include acetaminophen (Tylenol) and noncopyrightal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen (Advil, Motrin), and naproxen (Aleve, Naprosyn). NSAIDs can reduce fever and pain, and swelling from arthritis Curing anxiety or muscle sprains. However, they can cause stomach upset or ulcers in some peo